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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NCAPH All Species: 11.52
Human Site: S457 Identified Species: 21.11
UniProt: Q15003 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15003 NP_056156.2 741 82563 S457 R R K Q D A P S Q S E N K K K
Chimpanzee Pan troglodytes XP_001148661 741 82518 S457 R R K Q D A P S Q S E N K K K
Rhesus Macaque Macaca mulatta XP_001097565 209 22886
Dog Lupus familis XP_532948 916 102619 S493 R H K H D A S S K S E Y K K K
Cat Felis silvestris
Mouse Mus musculus Q8C156 731 82284 S450 R P K Q D A T S C T E H K K K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513175 869 95987 D587 R H K Q G A T D T S Q N K K K
Chicken Gallus gallus XP_001231605 383 41693 L124 I D Y M T D I L K Q K D S E L
Frog Xenopus laevis O13067 699 77759 D439 P R Q K A S T D S D Q Q R V K
Zebra Danio Brachydanio rerio NP_001073665 690 76324 P431 G H K Q D Q K P D K E P R K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001187579 678 74012 R420 A S K K P L F R L N Y D G D I
Poplar Tree Populus trichocarpa XP_002321137 605 68469 F347 N P D T D D R F D K V D W P L
Maize Zea mays NP_001144998 674 75246 G416 S K A N A W A G P E H W K Y R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_180818 671 75347 K413 W A G P D H W K Y R K T K G P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 27.1 67.4 N.A. 77.8 N.A. N.A. 58 29 54.7 46.9 N.A. N.A. N.A. N.A. 35
Protein Similarity: 100 99.4 27.9 71.8 N.A. 83.8 N.A. N.A. 67 38.5 69.2 61.4 N.A. N.A. N.A. N.A. 50.6
P-Site Identity: 100 100 0 66.6 N.A. 66.6 N.A. N.A. 60 0 13.3 33.3 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 0 73.3 N.A. 80 N.A. N.A. 66.6 26.6 46.6 46.6 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: 25.6 25.2 N.A. 23.7 N.A. N.A.
Protein Similarity: 43 41.8 N.A. 42.2 N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. 13.3 N.A. N.A.
P-Site Similarity: 13.3 20 N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 16 39 8 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 8 8 0 54 16 0 16 16 8 0 24 0 8 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 39 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % F
% Gly: 8 0 8 0 8 0 0 8 0 0 0 0 8 8 0 % G
% His: 0 24 0 8 0 8 0 0 0 0 8 8 0 0 0 % H
% Ile: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % I
% Lys: 0 8 54 16 0 0 8 8 16 16 16 0 54 47 47 % K
% Leu: 0 0 0 0 0 8 0 8 8 0 0 0 0 0 16 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 8 0 0 0 0 0 8 0 24 0 0 0 % N
% Pro: 8 16 0 8 8 0 16 8 8 0 0 8 0 8 8 % P
% Gln: 0 0 8 39 0 8 0 0 16 8 16 8 0 0 0 % Q
% Arg: 39 24 0 0 0 0 8 8 0 8 0 0 16 0 16 % R
% Ser: 8 8 0 0 0 8 8 31 8 31 0 0 8 0 0 % S
% Thr: 0 0 0 8 8 0 24 0 8 8 0 8 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % V
% Trp: 8 0 0 0 0 8 8 0 0 0 0 8 8 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 8 0 8 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _